James C Whisstock Selected Research

Pancreatic Elastase (Elastase)

11/2010

The subtilisin-like protease AprV2 is required for virulence and uses a novel disulphide-tethered exosite to bind substrates.

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James C Whisstock Research Topics

Disease

15	Neoplasms (Cancer) 12/2021 - 06/2005
8	Infections 10/2020 - 12/2003
8	Inflammation (Inflammations) 11/2019 - 11/2005
8	Thrombosis (Thrombus) 01/2019 - 02/2002
6	Malaria 09/2012 - 01/2010
4	Neoplasm Metastasis (Metastasis) 01/2020 - 10/2005
3	Emphysema 09/2011 - 07/2004
2	Disease Progression 10/2020 - 11/2010
2	Wounds and Injuries (Trauma) 01/2019 - 01/2019
2	Hemorrhage 01/2019 - 02/2002
2	Necrosis 01/2014 - 03/2010
2	Falciparum Malaria (Plasmodium falciparum Malaria) 09/2012 - 01/2012
2	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 12/2009 - 05/2008
2	Dementia (Dementias) 03/2008 - 07/2004
1	Hereditary Angioedemas 01/2022
1	Brain Neoplasms (Brain Tumor) 12/2021
1	Sarcoma (Soft Tissue Sarcoma) 12/2021
1	Neurofibromatosis 1 (Neurofibromatosis Type I) 12/2021
1	Gastrointestinal Diseases (Functional Gastrointestinal Disorders) 10/2020
1	Endotoxemia 10/2020
1	Extranodal Extension 01/2020
1	Ovarian Neoplasms (Ovarian Cancer) 01/2020
1	Hemorrhagic Disorders (Hemorrhagic Diathesis) 05/2017
1	Shock 02/2017
1	Alzheimer Disease (Alzheimer's Disease) 03/2016
1	Autistic Disorder (Autism) 01/2016
1	Breast Neoplasms (Breast Cancer) 08/2015
1	Enteritis 02/2013
1	Animal Diseases 02/2013
1	Movement Disorders (Movement Disorder) 01/2013
1	Fibrosis (Cirrhosis) 09/2011
1	Prostatic Neoplasms (Prostate Cancer) 04/2010
1	Seizures (Absence Seizure) 02/2010

Drug/Important Bio-Agent (IBA)

15	Proteins (Proteins, Gene)FDA Link 12/2021 - 12/2003
8	Peptide Hydrolases (Proteases)FDA Link 10/2020 - 10/2003
7	SerpinsIBA 03/2008 - 04/2002
6	SERPIN-B5 (maspin)IBA 01/2017 - 06/2005
5	AminopeptidasesIBA 09/2012 - 01/2010
4	PlasminogenIBA 01/2022 - 05/2017
3	Enzyme Precursors (Zymogens)IBA 10/2020 - 05/2017
3	Fibrinolysin FDA Link 10/2020 - 05/2017
3	Cytotoxins (Cytolysins)IBA 01/2020 - 10/2006
3	Serine Proteases (Serine Protease)IBA 01/2019 - 12/2003
3	PerforinIBA 01/2018 - 06/2009
3	Pharmaceutical PreparationsIBA 03/2016 - 02/2010
3	EnzymesIBA 03/2016 - 03/2011
3	Amino Acids FDA Link 01/2012 - 04/2005
3	Cysteine Proteases (Cysteine Protease)IBA 03/2010 - 04/2002
2	AntibodiesIBA 01/2020 - 12/2003
2	Antifibrinolytic Agents (Antifibrinolytics)IBA 01/2019 - 01/2019
2	VaccinesIBA 12/2017 - 02/2013
2	CaspasesIBA 01/2014 - 03/2010
2	Virulence Factors (Pathogenicity Factors)IBA 02/2013 - 10/2003
2	gamma-Aminobutyric Acid (GABA)IBA 01/2013 - 02/2010
2	PolymersIBA 09/2011 - 03/2008
2	ubenimexIBA 08/2011 - 03/2011
2	Antimalarials (Antimalarial Agents)IBA 08/2011 - 01/2010
2	Complement System Proteins (Complement)IBA 08/2009 - 11/2005
2	chenodeoxycholate sulfate conjugate (CDCS)IBA 09/2008 - 09/2007
2	NeuroserpinIBA 03/2008 - 12/2006
2	Heparin (Liquaemin)FDA LinkGeneric 12/2006 - 03/2004
2	von Willebrand FactorIBA 09/2006 - 02/2002
2	AntithrombinsIBA 03/2004 - 09/2003
1	AcidsIBA 01/2022
1	BradykininIBA 01/2022
1	Lysine (L-Lysine)FDA Link 01/2022
1	Neurofibromin 1 (Neurofibromin)IBA 12/2021
1	GuanosineIBA 12/2021
1	Dual-Specificity PhosphatasesIBA 01/2021
1	phosphoinositide-3,4,5-triphosphateIBA 01/2021
1	InflammasomesIBA 10/2020
1	Interleukin-18 (Interleukin 18)IBA 10/2020
1	Gemcitabine FDA Link 01/2020
1	ZirconiumIBA 01/2020
1	Membrane Proteins (Integral Membrane Proteins)IBA 01/2020
1	Radioisotopes (Radionuclides)IBA 01/2020
1	FibrinIBA 01/2019
1	Interleukin-2 (IL2)IBA 12/2017
1	Chimeric Antigen ReceptorsIBA 12/2017
1	CytokinesIBA 02/2017
1	Interleukin-1 (Interleukin 1)IBA 02/2017
1	ParvalbuminsIBA 01/2016
1	Botulinum Toxins (Botulinum Toxin)IBA 08/2015
1	GTP Phosphohydrolases (GTPases)IBA 08/2015
1	Rho Guanine Nucleotide Exchange FactorsIBA 08/2015
1	Phosphatidylinositols (Phosphatidylinositol)IBA 08/2015
1	Granzymes (Granzyme)IBA 01/2014
1	Hemolysin Proteins (Hemolysins)IBA 02/2013
1	Aminobutyrates (Aminobutyric Acid)IBA 01/2013
1	Peptides (Polypeptides)IBA 09/2012
1	Antisense RNA (Anti-Sense RNA)IBA 09/2012
1	Exopeptidases (Exopeptidase)IBA 01/2012
1	Fluorescent Dyes (Fluorescent Probes)IBA 01/2012
1	Mutant Proteins (Protein, Mutant)IBA 09/2011
1	Peptidylprolyl Isomerase (Prolyl Isomerase)IBA 06/2011
1	Pancreatic Elastase (Elastase)IBA 11/2010

Therapy/Procedure

4	Therapeutics 03/2014 - 03/2004
2	Immunotherapy 12/2017 - 06/2015
1	Aftercare (After-Treatment) 12/2017
1	Drug Therapy (Chemotherapy) 08/2011